Royal Air Force Typhoon jets have joined forces with French aircraft in a joint strike targeting an hidden munitions depot in Syria employed by the IS group, according to the UK's MoD.
The location, located using reconnaissance, was assessed as storing arms and explosives, the statement said, and was positioned in hills just north of the historic site of Palmyra in central Syria.
"The RAF jets used precision-guided Paveway IV munitions to strike a several approach shafts down to the site... initial indications suggest the strike was effective," the MoD said.
There was no indication of any civilian impact in the strike on Saturday evening and each participating jet returned safely, the MoD added.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
Daesh - alternatively referred to as ISIS - established militant control over large swathes of Syria and Iraq prior to its 2019 collapse.
"This action shows our UK leadership, and determination to work closely with our allies, to stamp out any revival of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary remarked.
RAF aircraft have carried out surveillance missions over Syrian airspace to "prevent any attempted comeback" of IS following its routing at the climactic battle in Baghuz in 2019, the MoD reported.
"I must thank the personnel of British forces involved in this operation for their professionalism and their courage," he commented. "They were part of thousands of UK service members deployed over the festive period. This operation, to eliminate dangerous terrorists who threaten our way of life, demonstrates how our armed forces are ready to step up, continuously, ensuring Britain's security domestically and powerful internationally."
During December, the US military carried out what it termed a "large-scale strike" targeting Islamic State objectives in the country, after an assault claimed the lives of two US servicemembers and a civilian linguist in Palmyra.
The UN reports Islamic State still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.